英文名称 |
Anti-EMR1 Polyclonal Antibody |
中文名称 |
粘附G蛋白偶联受体E1抗体 |
宿主 |
Rabbit |
克隆类型 |
Polyclonal Antibody |
亚型 |
IgG |
稀释比例 |
WB 1:500-2000. IHC 1:400-1600. IF 1:50-500. |
靶标 |
EMR1 |
别名 |
ADGRE1, Adhesion G protein-coupled receptor E1, EGF like module receptor 1, EMR1, EMR1 hormone receptor, F4/80, TM7LN3 |
背景说明 |
EMR1 (EGF-like module containing mucin-like hormone receptor 1), also known as Adhesion G protein-coupled receptor E1 (ADGRE1), is a surface receptor with seven transmembrane segments that belongs to the EGF-7-transmembrane family of G protein-coupled receptors (PMID: 14647991, 7601460). EMR1 expression is restricted to eosinophilic granulocytes, where expression is overlapping with the eotaxin receptor CCR3 and the immunoglobulin-like lectin Siglec-8. Absence on other leukocytes, including basophils, implies that EMR1 is a highly specific marker for eosinophils in humans and may be used as a novel therapeutic target for eosinophilic disorders(PMID: 17823986, 24530099). F4/80, the murine homolog of EMR1, is a marker of murine macrophage. The apparent molecular weigh of F4/80 is 160 kDa, which is lager than the calculated molecular weight due to post-translational modifications (PMID: 7308288; 8647179). |
Swiss Prot |
Q14246 |
Gene ID |
2015 |
亚细胞定位 |
Cell membrane Multi-pass membrane protein |
免疫原 |
Recombinant protein of human EMR1 |
Public Immunogen Range |
430-510aa |
理论分子量 |
90kDa |
纯化方法 |
Affinity purification |
储存液 |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
储存条件 |
Store at -20℃. Avoid freeze / thaw cycles.
|
规格 |
50ul 100ul |
交叉反应 |
Human Mouse |
应用 |
WB IHC IF ELISA |
研究领域 |
免疫学 表观遗传 |
单位 |
支 |
属性分类 |
其他抗体 |