基因名 |
TIA1 |
别名 |
TIA-1;WDM;nucleolysin TIA-1 isoform p40 |
英文名称 |
Recombinant human TIA1 protein |
全名 |
cytotoxic granule-associated RNA binding protein |
中文名称 |
细胞毒颗粒RNA结合蛋白 |
外观(性状) |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.) |
纯度 |
≥85% by SDS-PAGE. |
储存条件 |
Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year. |
运输条件 |
The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
浓度 |
1mg/ml by SDS-PAGE. |
Swiss Prot |
P31483 |
Gene ID |
7072 |
交叉反应 |
Human Mouse |
分子量 |
24kDa |
区间范围 |
1-194aa |
背景说明 |
The product encoded by this gene is a member of a RNA-binding protein family and involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs).Possesses nucleolytic activity against cytotoxic lymphocyte target cells.It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets.The major granule-associated species is a 15-kDaa protein that is thought to be derived from the carboxyl terminus of the 40-kDaa product by proteolytic processing.Alternative splicing resulting in different isoforms of this gene product has been described in the literature. |
应用 |
Immunology research |
来源 |
E.coli |
纯化方法 |
NI-NTA affinity purification |
溶剂 |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
内毒素 |
Not measured |
生物活性 |
NO |
标签信息 |
With a 6×His tag at the N/C-terminus. |
规格 |
10ug 50ug 100ug 1mg |
单位 |
支 |
属性分类 |
重组抗原 |