英文名称 |
Anti-CDK2 Polyclonal Antibody |
中文名称 |
周期蛋白-依赖性蛋白激酶2抗体 |
宿主 |
Rabbit |
克隆类型 |
Polyclonal Antibody |
亚型 |
IgG |
预测交叉反应 |
Cow(100%);Hamster(100%);Fish(100%) |
稀释比例 |
IHC 1:25-100. |
靶标 |
CDK2 |
别名 |
Cdc2 related protein kinase, cdc2-related protein kinase, Cdk 2, CDK2_HUMAN, Cell devision kinase 2, Cell division kinase 2, Cell division protein kinase 2, Cyclin dependent kinase 2, cyclin dependent kinase 2-alpha, Cyclin-dependent kinase 2, p33 protein kinase, p33(CDK2) |
背景说明 |
Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). |
Swiss Prot |
P24941 |
Gene ID |
1017 |
亚细胞定位 |
Cytoplasm Nucleus |
免疫原 |
A synthetic peptide of Human CDK2 |
Public Immunogen Range |
220-270/298aa |
理论分子量 |
30/34kDa |
纯化方法 |
Affinity purification |
储存液 |
PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3. |
储存条件 |
Store at -20℃. Avoid freeze/thaw cycles. |
运输条件 |
冷冻运输 |
规格 |
20ul 50ul 100ul |
交叉反应 |
Human Rat Mouse |
应用 |
IHC |
研究领域 |
细胞生物学 表观遗传 |
单位 |
支 |
属性分类 |
其他抗体 |