| 别名 |
5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor,Serotonin receptor 2A,5-HT-2A,5-HT-2,HTR2A,Htr2a,5 HT 2,5HTR2A,5 HT 2A,5 HT2 receptor,5 HT2A,5 hydroxytryptamine receptor 2A,5-HT-2,5-HT-2A,5-hydroxytryptamine 2A receptor,5-hydroxytryptamine receptor 2A,5HT2A_HUMAN,HTR 2,HTR 2A,HTR2,HTR2A |
| 背景说明 |
G-protein coupled receptor for 5-hydroxytryptamine. Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.Acts as a receptor for human JC polyomavirus/JCPyV. |
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