英文名称 |
Anti-RIPK1 Polyclonal Antibody |
中文名称 |
受体相互作用丝氨酸-苏氨酸激酶1 |
宿主 |
Rabbit |
克隆类型 |
Polyclonal Antibody |
亚型 |
IgG |
稀释比例 |
WB 1:2000-5000. IHC 1:25-100. IF 1:50-200. ELISA 1:3000-30000. |
靶标 |
RIPK1 |
别名 |
Cell death protein RIP; FLJ39204; OTTHUMP00000039163; Receptor (TNFRSF) interacting serine threonine kinase 1; receptor interacting protein 1; Receptor interacting protein; Receptor interacting protein kinase 1; Receptor interacting serine threonine protein kinase 1; Receptor TNFRSF interacting serine threonine kinase 1; Receptor-interacting protein 1; Receptor-interacting serine/threonine-protein kinase 1; Rinp; RIP 1; RIP; Rip-1; RIP1; RIPK 1; Ripk1; RIPK1_HUMAN; Serine threonine protein kinase RIP; Serine/threonine-protein kinase RIP; |
背景说明 |
Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:32657447, PubMed:31827280, PubMed:31827281).Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283).Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, in part, by activating the canonical NF-kappa-B pathway (By similarity). |
Swiss Prot |
Q13546 |
Gene ID |
8737 |
亚细胞定位 |
Cytoplasm Cell membrane |
免疫原 |
Recombinant protein of human RIPK1 |
Public Immunogen Range |
171-487aa |
理论分子量 |
71/76kDa |
实际分子量 |
77kDa |
纯化方法 |
Affinity purification |
储存液 |
PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3. |
储存条件 |
Store at -20℃. Avoid freeze / thaw cycles. |
规格 |
20ul 50ul 100ul |
交叉反应 |
Human |
应用 |
WB IHC IF ELISA |
研究领域 |
肿瘤&癌症 心血管 细胞生物学 发育生物学 信号传导 |
单位 |
支 |
属性分类 |
其他抗体 |