英文名称 |
Anti-EXD2 Polyclonal Antibody |
中文名称 |
核酸外切酶3'-5'结构域样2 |
宿主 |
Rabbit |
克隆类型 |
Polyclonal Antibody |
亚型 |
IgG |
稀释比例 |
WB 1:2000-5000. IHC 1:25-100. IF 1:50-200. |
靶标 |
EXD2 |
别名 |
C14orf114;chromosome 14 open reading frame 114;DKFZp781A0133;DKFZp781L15100;EXDL2;exonuclease 3'-5' domain containing 2;exonuclease 3'-5' domain-containing protein 2;exonuclease 3'-5' domain-like 2;Exonuclease 3'-5' domain-like-containing protein 2;FLJ10738; |
背景说明 |
Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291).In presence of Mg2+, only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn2+ (PubMed:29335528, PubMed:31127291).Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528).Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466).Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646).Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646).Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466). |
Swiss Prot |
Q9NVH0 |
Gene ID |
55218 |
亚细胞定位 |
Cytoplasm Nucleus |
免疫原 |
Recombinant protein of human EXD2 |
Public Immunogen Range |
273-621aa |
理论分子量 |
56/70kDa |
实际分子量 |
70kDa |
纯化方法 |
Affinity purification |
储存液 |
PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3. |
储存条件 |
Store at -20℃. Avoid freeze / thaw cycles. |
规格 |
20ul 50ul 100ul |
交叉反应 |
Human Mouse |
应用 |
WB IHC IF |
单位 |
支 |
属性分类 |
其他抗体 |