| CAS |
No.124436-59-5 |
| 中文名称 |
吡罗达韦 |
| 英文名称 |
Pirodavir |
| 别名 |
吡罗达韦;(+)-3，4-DidehydrocoronaridineSulfate |
| 分子式 |
C21H27N3O3 |
| 分子量 |
369.46 |
| 溶解性 |
Soluble in DMSO(Need ultrasonic) |
| 纯度 |
≥98% |
| 外观(性状) |
Light yellow to yellow Solid |
| 储存条件 |
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| 运输条件 |
冷藏运输 |
| MDL |
MFCD00866965 |
| SMILES |
CCOC(=O)C1=CC=C(C=C1)OCCC2CCN(CC2)C3=NN=C(C=C3)C |
| InChIKey |
KCHIOGFOPPOUJC-UHFFFAOYSA-N |
| InChI |
InChI=1S/C21H27N3O3/c1-3-26-21(25)18-5-7-19(8-6-18)27-15-12-17-10-13-24(14-11-17)20-9-4-16(2)22-23-20/h4-9，17H，3，10-15H2，1-2H3 |
| PubChem CID |
71345 |
| 靶点 |
Rhinovirus;Picornaviridae |
| 通路 |
Anti-infection |
| 背景说明 |
Pirodavir 是一种有效的小核糖核酸病毒抑制剂，高效作用于 A 和 B 型鼻病毒(rhinovirus)。 |
| 生物活性 |
Pirodavir 是一种强效、广谱的核糖核酸病毒抑制剂，对 A 组和 B 组鼻炎病毒血清型均有很高的活性，其 IC90=2.3 nM。[1-2] |
| In Vitro |
Pirodavir inhibited 59% of the serotypes and isolates.[1] Pirodavir inhibits 80% of 100 serotypes tested(EC80)at 0.064 micrograms/ml. The mode of action appears to be serotype specific，pirodavir was able to inhibit the adsorption of human rhinovirus 9 but not that of human rhinovirus 1A. Pirodavir is a novel capsid-binding antipicornavirus agent with potent in vitro activity against both group A and group B rhinovirus serotypes.[2] |
| 数据来源文献 |
[1]. Barnard DL，et al. In vitro activity of expanded-spectrum pyridazinyl oxime ethers related to pirodavir: novel capsid-binding inhibitors with potent antipicornavirus activity. Antimicrob Agents Chemother. 2004 May;48(5):1766-72.
[2]. Andries K，et al. In vitro activity of pirodavir (R 77975)，a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity. Antimicrob Agents Chemother. 1992 Jan;36(1):100-7. |
| 规格 |
1mg 2mg 5mg 10mg 25mg |
| 单位 |
瓶 |
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