抗坏血酸钠_维生素及其衍生物_小分子化合物_索莱宝-专业生化试剂网上商城

SKU	北京总部	北京海淀	武汉	广州
IS2410-100mg	咨询	咨询	咨询	咨询
IS2410-200mg	咨询	咨询	咨询	咨询
IS2410-500mg	咨询	咨询	咨询	咨询
IS2410-1mL	咨询	咨询	咨询	咨询

CAS	134-03-2
中文名称	抗坏血酸钠
英文名称	Sodium Ascorbate
别名	维生素C钠;L-抗坏血酸钠;VC钠盐;NaVc
纯度	≥98%
分子式	C₆H₇NaO₆
分子量	198.11
外观（性状）	Off-white to light yellow Solid
储存条件	Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
溶解性	Soluble in Water ≥10mg/mL
MDL	MFCD00082340
EC	EINECS 205-126-1
SMILES	C(C(C1C(=C(C(=O)O1)O)[O-])O)O.[Na+]
描述	Sodium Ascorbate是一种电子供体和内源性抗氧化剂,选择性抑制 Cav3.2 channels。(Sodium Ascorbate is an electron donor and endogenous antioxidant that selectively inhibits Cav3.2 channels.)
靶点	Cav3.2 channels
通路	Membrane Transporter&Ion Channel;Neuronal Signaling
生物活性	L-Ascorbic acid sodium salt (Sodium L-ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor[1-3].
In Vitro	The conditioned medium for B16F10 cells significantly inhibits cell apoptosis induced by L-Ascorbic acid sodium salt (Sodium L-ascorbate) (10 mM), and the effective ingredients in the medium show a relative molecular mass below 5,000[4].
In Vivo	Tg rats treated with L-Ascorbic acid sodium salt (Sodium L-ascorbate) show a higher incidence of carcinoma (29.6%), compared to those without L-Ascorbic acid sodium salt (15.4%). Independent of the L-Ascorbic acid sodium salt treatment, transgenic rats exhibit various kinds of malignant tumors in various organs[5].
动物实验	A total of 40 7-week-old male Tg rats are divided into 2 groups. Twenty-seven (group 1) and 13 (group 2) rats are given a powdered MF diet with or without 5% sodium L-ascorbate, respectively. Similarly, a total of 42 7-week-old male Non-tg rats are divided into 2 groups, and 30 (group 3) and 12 (group 4) animals are given a diet with or without 5% sodium L-ascorbate, respectively.[3]
数据来源文献	[1]. Hinek A, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [2]. Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [3]. Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83. [4]. Yang X, et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50. [5]. Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7. [6]. Takagi H, et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53.
规格	100mg 10mM*1mL in Water 200mg 500mg
单位	瓶