中文
英语
雷帕霉素
CAS:No.53123-88-9
分子式:C51H79NO13
分子量:914.18
储存条件:-20℃，避光防潮密闭保存，有效期2年
纯度:98.00%
英文名称:Rapamycin
产品简介
| 别名 | 西罗莫司 |
| 英文名称 | Rapamycin |
| CAS | No.53123-88-9 |
| 分子式 | C51H79NO13 |
| 分子量 | 914.18 |
| 储存条件 | -20℃，避光防潮密闭保存，有效期2年 |
| 外观(性状) |
白色粉末
|
| 纯度 | 98.00% |
| 溶解性 | DMSO 25mg/ml |
| 规格 | 25mg |
| 单位 | 支 |
用途及描述：科研试剂，广泛应用于分子生物学，药理学等科研方面。本品抑制由抗原和细胞因子（白介素IL-2、IL-4和IL-15）激发的T淋巴细胞的活化和增殖，它亦抑制抗体的产生。在细胞中，西罗莫司与免疫嗜素，即FK结合蛋白-12（FKBP-12）结合，生成FKBP-12免疫抑制复合物。此复合物与哺乳动物的西罗莫司BA分子（mTOR，一种关键的调节激酶）结合并抑制其活性，从而抑制细胞周期中G1期向S期的发展。
Product Description
Macrocyclic-triene antibiotic possessing potent immunosuppressant activity. It forms a complex with FKBP12 that binds to an effector, thus inhibiting IL-2 and other growth promoting lymphokines. The effectors were recently identified as FRAP (FKBP12 rapamycin-associated protein) and RAFT1 (rapamycin and KFBP12target). Rapamycin induces inhibition of p70s6k, p33cdk2 and p34cdc2. Enhances apoptosis.SOURCE/HOST: Isolated from Streptomyces hygroscopicus.
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in chloroform, DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.
备注：产品信息可能会有优化升级。请以实际标签信息为准。
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these
methods.
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PMID：
36172090
Physcion, a novel anthraquinone derivative against Chlamydia psittaci infection
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Author：
Xinyi Liu, Huilong Hu, Jiaqi Liu, Jiaqi Chen, Jun Chu, He Cheng
IF：
3.3000
Publish_to：
VETERINARY MICROBIOLOGY
PMID：
36716634
Electroacupuncture Activates Neuroplasticity in the Motor Cortex and Corticospinal Tract via the mTOR Pathway in a Rat P-MCAO Model
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Author：
You Zhang, Ya-Long Yin, Zi-Yan Jin, Qi-Ping Hu, Xin-gui Wu
IF：
3.2460
Publish_to：
Biomed Research International
PMID：
36440366
Knockdown of ETV4 promotes autophagy‑dependent apoptosis in GBM cells by reducing the transcriptional activation of EMP1
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Author：
Junxiang Wang, Chengfa Sun, Jian Li, Hua Jiang, Yun Qiu, Mingjie Gong
IF：
2.9670
Publish_to：
Oncology Letters
PMID：
34976153
Aucubin alleviates methotrexate-induced enteritis in rats by inducing autophagy
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Author：
Tongao Yang, Wuying Lang, Yun Zhao, Yahan Yang, Hongli Liu, Sufen Li, Xianglong Li, Shuangqi Zhang, Haihua Zhang
IF：
2.9000
Publish_to：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
PMID：
37582493
Effect of autophagy on aging-related changes in orthodontic tooth movement in rats
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Author：
Xu Bowen, Peng Chuhan, Du Yugui, Li Qiuying, Yang Kai
IF：
2.6000
Publish_to：
BMC Oral Health
PMID：
38997686
Dendrobium nobile Lindl. alkaloids protect CCl4-induced acute liver injury via upregulating LAMP1 expression and activating autophagy flux
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Author：
Nan Nan, Yang Yonggang, Fu Xiaolong, Xian Siting, Wu Qin, Shi Jingshan, Zhou Shaoyu
IF：
2.5000
Publish_to：
Journal of Natural Medicines
PMID：
39546174
Effect of Neiyi Prescription of QIU on autophagy and angiogenic ability of endometriosis via the PPARγ/NF-κB signaling pathway
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Author：
Yang Hua-Di, Zhu Qun-Fei, Li Hui, Jiang Xue-Lu, Xu Xu-Qun, Guo Yong
IF：
2.4930
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ARCHIVES OF GYNECOLOGY AND OBSTETRICS
PMID：
35366690
IL-17A is involved in the hyperplasia of blood vessels in local lesions of psoriasis by inhibiting autophagy
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Author：
Juanjuan Wang, Ling Zhou, Hui Hou, Jiao Li, Xincheng Zhao, Jiajie Li, Junqin Li, Xuping Niu, Ruixia Hou, Kaiming Zhang
IF：
2.3000
Publish_to：
Journal of Cosmetic Dermatology
PMID：
37635345
Rapamycin relieves lupus nephritis by regulating TIM-3 and CD4+CD25+Foxp3+ Treg cells in an MRL/lpr mouse model
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Author：
Yan-fang Gao, Xiu-zhao Fan, Rong-shan Li, Xiao-shuang Zhou
IF：
1.6340
Publish_to：
Central European Journal of Immunology
PMID：
36817267
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雷帕霉素细胞实验怎么配置，100nM时会从培养基中析出?2023-04-05 22:33:54
您好，溶解性：25 mg/mL in DMSO，细胞实验保证DMSO含量为千分之一。