中文
英语
产品简介
| 别名 | 细胞核蛋白提取试剂盒 |
| 英文名称 | Nuclear Protein Extraction Kit |
| 中文名称 | 核蛋白提取试剂盒 |
| 储存条件 | 附件PMSF-20℃，其它试剂4℃。有效期1年 |
| 规格 | 50T 100T |
| 单位 | 盒 |
产品简介：本核蛋白提取试剂盒提供了一种简单、方便的从培养细胞或新鲜组织中抽提核蛋白的方法。整个过程只需约60分钟就可以将核蛋白和浆蛋白从细胞中分离出来。得到的蛋白可以用于Western blot等实验。本试剂盒通过浆蛋白抽提试剂使细胞膨胀破裂，释放出胞浆蛋白，再通过离心得到细胞核。然后通过核蛋白抽提试剂抽提得到细胞核蛋白。本试剂盒可以抽提50/100个样品（每个样品约2×106个Hela细胞或40mg组织）。
规格：50T/100T
产品内容：
| 试剂盒组成 | 50T | 100T |
| 浆蛋白抽提试剂 | 25ml | 50ml |
| 核蛋白抽提试剂 | 5ml | 10ml |
| PMSF（100mM） | 300μl | 1ml |
保存：核/浆蛋白抽提试剂4℃保存，PMSF于-20℃保存。
操作方法：
裂解蛋白的所有步骤都需在冰上或4℃进行。
一、对于体外培养细胞：
1．根据用量取适当的浆蛋白抽提试剂和核蛋白抽提试剂加入PMSF，使PMSF的最终浓度为1mM。PMSF需现用现加，若目标蛋白含有丰富的半胱氨酸，可以在两种蛋白抽提液中加入DTT至终浓度0.5mM。
2．对于贴壁细胞，去除培养液，用PBS洗一遍，用细胞刮刀收集细胞，或用EDTA消化后吹打下细胞（最好不用胰酶硝化，以免胰酶消化目的蛋白）。500 g离心2～3分钟收集细胞，吸尽上清留下沉淀备用。
3．对于悬浮细胞：用PBS洗一遍，500 g离心2～3分钟收集细胞，吸尽上清，留下细胞沉淀备用。
4．每20μl细胞沉淀加入200μl浆蛋白抽提试剂（2×106个细胞沉淀的体积约20μl或40mg）。
5．用移液器吹打或高速涡旋15秒（可适当延长），必须使细胞沉淀完全分散开成单细胞悬液。细胞沉淀分散不完全会导致蛋白产量降低。
6．冰浴10分钟。
7．最高转速剧烈涡旋10秒，4℃ 12000～16000g离心10分钟。
8．上清即为抽提得到的细胞浆蛋白，立即吸取上清至预冷的样品管中备用，进行后续的PAGE、Western等实验，但蛋白浓度较低，可根据需要进行相应浓缩。
9．沉淀即为细胞核，要完全吸尽残余的上清（避免细胞浆蛋白的污染），加入50-100μl核蛋白抽提试剂。
10．用移液器吹打或高速涡旋15秒（可适当延长）至沉淀完全分散，冰浴10分钟。
11．最高转速剧烈涡旋10秒，4℃12000～16000g离心10分钟。12．立即吸取上清至预冷的样品管中，此即为抽提得到的细胞核蛋白。可进行后续实验或-70℃冻存。 对于组织样品： 把组织称重后，尽可能切成非常细小的碎片，按每50mg组织加入200μl-500μl PBS，用匀浆器冰上匀浆制成细胞悬液，500 g离心2～3分钟收集细胞，吸尽上清，收集沉淀。加入200μl浆蛋白抽提试剂后接上述步骤5。
注意事项：
1．裂解得到的蛋白样品，由于含有较高浓度的去垢剂干扰，不能用Bradford法测定蛋白浓度，可以选用本公司生产的BCA蛋白定量试剂盒(货号PC0020)测定蛋白浓度。
2．对于组织样品，本试剂盒适用于新鲜组织，对冻存组织抽提效果较差。
3．为了您的安全和健康，请穿实验服并戴一次性手套操作。
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these
methods.
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PMID：
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Supplementation of nicotinamide mononucleotide diminishes COX-2 associated inflammatory responses in macrophages by activating kynurenine/AhR signaling
点击查看 >>
Author：
Jing Liu, Wenxuan Hou, Zhaoyun Zong, Yuling Chen, Xiaohui Liu, Ran Zhang, Haiteng Deng
IF：
7.4000
Publish_to：
FREE RADICAL BIOLOGY AND MEDICINE
PMID：
38336100
Role of the SENP1–SIRT1 pathway in hyperoxia-induced alveolar epithelial cell injury
点击查看 >>
Author：
Wenbin Dong, Xiaodan Zhu, Xingling Liu, Xu Zhao, Xiaoping Lei, Lan Kang, Li Liu
IF：
7.3760
Publish_to：
FREE RADICAL BIOLOGY AND MEDICINE
PMID：
34311030
Vitamin C Sensitizes Pancreatic Cancer Cells to Erastin-Induced Ferroptosis by Activating the AMPK/Nrf2/HMOX1 Pathway
点击查看 >>
Author：
Yawen Liu, Pu Huang, Zheng Li, Chunhui Xu, Huizhi Wang, Baoqing Jia, Aihua Gong, Min Xu
IF：
7.3100
Publish_to：
Oxidative Medicine and Cellular Longevity
PMID：
35915609
Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-百B signaling cascade and inhibiting NLRP3 inflammasome activation
点击查看 >>
Author：
Shun Tang, Yuanjing Liang, Minmin Wang, Jiarong Lei, Yuhui Peng, Qiu Tao, Tianqi Ming, Wenyu Yang, Chuantao Zhang, Jinlin Guo, Haibo Xu
IF：
7.3000
Publish_to：
Frontiers in Immunology
PMID：
37954597
The water extract of Potentilla discolor Bunge (PDW) ameliorates high-sugar diet-induced type II diabetes model in Drosophila melanogaster via JAK/STAT signaling
点击查看 >>
Author：
Lin Niu, Yu-jie Lu, Xing-wang Zu, Wen Yang, Fu-kui Shen, Yan-yan Xu, Min Jiang, Yang Xie, Su-yun Li, Jie Gao, Gang Bai
IF：
7.2000
Publish_to：
PHYTOTHERAPY RESEARCH
PMID：
37282760
PTPRO knockdown protects against inflammation in hemorrhage shock-induced lung injury involving the NF-κB signaling pathway
点击查看 >>
Author：
Huan Zhirong, Tang Ying, Xu Ce, Cai Jimin, Yao Hao, Wang Yan, Bu Fanyu, Ge Xin
IF：
7.1620
Publish_to：
RESPIRATORY RESEARCH
PMID：
35906634
TAZ promotes osteogenic differentiation of mesenchymal stem cells line C3H10T1/2, murine multi-lineage cells lines C2C12, and MEFs induced by BMP9
点击查看 >>
Author：
Huang Huakun, Lu Qiuping, Ye Caihong, Wei Mengqi, Yang Chunmei, Zhang Lulu, Huang Yanran, Luo Xiaoji, Luo Jinyong
IF：
7.1090
Publish_to：
Cell Death Discovery
PMID：
36575168
Identification of Cytochrome P450 2E1 as a Novel Target in Neuroinflammation and Development of Its Inhibitor Q11 as a Treatment Strategy
点击查看 >>
Author：
Rui Yang, Meng-Yan Deng, Lu-Kui Yang, Guan-Zhe Wang, Jun Ma, Qiang Wen, Na Gao, Hai-Ling Qiao
IF：
7.1000
Publish_to：
FREE RADICAL BIOLOGY AND MEDICINE
PMID：
40122152
Mori fructus aqueous extracts attenuates liver injury by inhibiting ferroptosis via the Nrf2 pathway
点击查看 >>
Author：
Wei Yuanyuan, Gao Chen, Wang Huiru, Zhang Yannan, Gu Jinhua, Zhang Xiuying, Gong Xuhao, Hao Zhihui
IF：
7.0000
Publish_to：
Journal of Animal Science and Biotechnology
PMID：
37032323
Black mulberry (Morus nigra L.) polysaccharide ameliorates palmitate-induced lipotoxicity in hepatocytes by activating Nrf2 signaling pathway
点击查看 >>
Author：
Wei Chen, Yang Lu, Dongwen Hu, Jianling Mo, Jingdan Ni
IF：
6.9530
Publish_to：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
PMID：
33450344
Transcription Coactivator BCL3 Acts as a Potential Regulator of Lipid Metabolism Through the Effects on Inflammation
点击查看 >>
Author：
Shuo Zhang, Jingtao Gao, Shibo Liu, Lu Yu, Wen Zhang, Yinming Liang, Hui Wang
IF：
6.9220
Publish_to：
Journal of Inflammation Research
PMID：
34588797
Suppression of NOD-like receptor protein 3 inflammasome activation and macrophage M1 polarization by hederagenin contributes to attenuation of sepsis-induced acute lung injury in rats
点击查看 >>
Author：
Lin Wang, Min Zhao
IF：
6.8320
Publish_to：
Bioengineered
PMID：
35266443
SAFA initiates innate immunity against cytoplasmic RNA virus SFTSV infection
点击查看 >>
Author：
刘斌堰
IF：
6.8230
Publish_to：
plos pathogens
PMID：
34788350
The mechanism of nickel-induced autophagy and its role in nephrotoxicity
点击查看 >>
Author：
Heng Yin, Chengbi Wang, Hongrui Guo, Xiaocong Li, Jingbo Liu
IF：
6.8000
Publish_to：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
PMID：
38430579
Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB
点击查看 >>
Author：
Wang Wanyue, Li Xin, Xu Ye, Guo Weikang, Yu Hui, Zhang Lu, Wang Yaoxian, Chen Xiuwei
IF：
6.7300
Publish_to：
CELLULAR ONCOLOGY
PMID：
33469837
C644‐0303, a small‐molecule inhibitor of the Wnt/β‐catenin pathway, suppresses colorectal cancer growth
点击查看 >>
Author：
Yu Yan, Yidan Zhang, Mengyuan Li, Yazhuo Zhang, Xinxin Zhang, Xiaonan Zhang, Yuting Xu, Wei Wei, Jie Wang, Xiaohan Xu, Qiaoling Song, Chenyang Zhao
IF：
6.7160
Publish_to：
CANCER SCIENCE
PMID：
34431598
Promoting Effect of L-Fucose on the Regeneration of Intestinal Stem Cells through AHR/IL-22 Pathway of Intestinal Lamina Propria Monocytes
点击查看 >>
Author：
Chen Tan, Gaichao Hong, Zhe Wang, Caihan Duan, Lingzhi Hou, Junhao Wu, Wei Qian, Chaoqun Han, Xiaohua Hou
IF：
6.7060
Publish_to：
Nutrients
PMID：
36432480
PRM1201 effectively inhibits colorectal cancer metastasis via shaping gut microbiota and short- chain fatty acids
点击查看 >>
Author：
Ru Jia, Shiyun Shao, Pingping Zhang, Yuan Yuan, Wenqing Rong, Ziming An, Sheng Lv, Yuanyuan Feng, Ningning Liu, Qin Feng, Yan Wang, Qi Li
IF：
6.7000
Publish_to：
PHYTOMEDICINE
PMID：
38878524
Selective Anti-melanoma Effect of Phosphothioated Aptamer Encapsulated by Neutral Cytidinyl/Cationic Lipids
点击查看 >>
Author：
Wu Jing, Wang Shuhe, Li Xiang, Zhang Qi, Yang Jie, Ma Yuan, Guan Zhu, Yang Zhenjun
IF：
6.6840
Publish_to：
Frontiers in Cell and Developmental Biology
PMID：
34262898
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro
点击查看 >>
Author：
Yue Shen, Xinting Fan, Yuhan Qu, Min Tang, Yuehui Huang, Yi Peng, Qiang Fu
IF：
6.6560
Publish_to：
PHYTOMEDICINE
PMID：
35870375
Overexpression of MsSAG113 gene promotes leaf senescence in alfalfa via participating in the hormone regulatory network
点击查看 >>
Author：
Shuwen Li, Hong Xie, Lingfang Zhou, Di Dong, Yaling Liu, Chenyan Jia, Liebao Han, Yuehui Chao, Yinglong Chen
IF：
6.6270
Publish_to：
Frontiers in Plant Science
PMID：
36570962
SRBI deficiency induces iron overload and ferroptosis in renal tubular epithelial cells via HIF-1α/TFR1 signaling pathway
点击查看 >>
Author：
Ms. Lijiao Yang, Ms. Qing Liu, Ms. Qianyu Lu, Dr. Jing-Jie Xiao, Mr. An-Yao Fu, Ms. Shan Wang, Ms. Lihua Ni, Mr. Jun-Wei Hu, Dr. Hong Yu, Prof. Xiaoyan Wu, Dr. Bai-Fang Zhang
IF：
6.6000
Publish_to：
ANTIOXIDANTS & REDOX SIGNALING
PMID：
38062756
Two Alkaloids From Delphinium brunonianum Royle, Their Anti-inflammatory and Anti-oxidative Stress Activity via NF-κB Signaling Pathway
点击查看 >>
Author：
Qi Tang, Sitan Chen, Syed Arif Hussain Rizvi, Jiaojiao Qu, Li Wang, Senye Wang, Changyang Ma, Lijun Liu, Wenyi Kang
IF：
6.5900
Publish_to：
Frontiers in Nutrition
PMID：
35127798
Origanum majorana L.: A Nutritional Supplement With Immunomodulatory Effects
点击查看 >>
Author：
Senye Wang, Li Zhou, Fatma Al-Zahra K. K. Attia, Qi Tang, Mengke Wang, Zhenhua Liu, Geoffrey I. N. Waterhouse, Lijun Liu, Wenyi Kang
IF：
6.5760
Publish_to：
Frontiers in Nutrition
PMID：
34631774
WSSV exploits AMPK to activate mTORC2 signaling for proliferation by enhancing aerobic glycolysis
点击查看 >>
Author：
Zhang Peng, Fu Hai-Jing, Lv Li-Xia, Liu Chen-Fei, Han Chang, Zhao Xiao-Fan, Wang Jin-Xing
IF：
6.5480
Publish_to：
Communications Biology
PMID：
37012372
Vortioxetine hydrobromide inhibits the growth of gastric cancer cells in vivo and in vitro by targeting JAK2 and SRC
点击查看 >>
Author：
Li Mingzhu, Duan Lina, Wu Wenjie, Li Wenjing, Zhao Lili, Li Ang, Lu Xuebo, He Xinyu, Dong Zigang, Liu Kangdong, Jiang Yanan
IF：
6.5240
Publish_to：
Oncogenesis
PMID：
37147297
Overexpression of a small GTP-binding protein Ran1 in Arabidopsis leads to promoted elongation growth and enhanced disease resistance against P. syringae DC3000
点击查看 >>
Author：
Peipei Xu, Wei Ma, Jing Liu, Jinbo Hu, Weiming Cai
IF：
6.4860
Publish_to：
PLANT JOURNAL
PMID：
34312926
Ammonia stress-induced heat shock factor 1 enhances white spot syndrome virus infection by targeting the interferon-like system in shrimp
点击查看 >>
Author：
Xin-Xin Wang, Hui Zhang, Jie Gao, Xian-Wei Wang
IF：
6.4000
Publish_to：
mBio
PMID：
38358252
Cucurbitacin IIb attenuates cancer cachexia induced skeletal muscle atrophy by regulating the IL-6/STAT3/FoxO signaling pathway
点击查看 >>
Author：
Yaxian Wang, Xipeng Sun, Quanjun Yang, Cheng Guo
IF：
6.3880
Publish_to：
PHYTOTHERAPY RESEARCH
PMID：
37073890
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen
点击查看 >>
Author：
Guifang Zhao, Ling Qi, Yanling Wang, Xinlian Li, Qiuyue Li, Xiaoqing Tang, Xiali Wang, Chunling Wu
IF：
6.2910
Publish_to：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
PMID：
34293585
Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/β-Catenin Signaling
点击查看 >>
Author：
Wang Chengqin, Zhang Runze, Wang Xiao, Zheng Yan, Jia Huiqing, Li Haiyan, Wang Jin, Wang Ning, Xiang Fenggang, Li Yujun
IF：
6.2440
Publish_to：
Frontiers in Oncology
PMID：
33542902
The protective effect of forsythiaside A on 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestatic liver injury in mice: Based on targeted metabolomics and molecular biology technology
点击查看 >>
Author：
Ke Fu, Shu Dai, Yanzhi Li, Cheng Ma, Xinyan Xue, Shenglin Zhang, Cheng Wang, Honglin Zhou, Yafang Zhang, Yunxia Li
IF：
6.2000
Publish_to：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
PMID：
37523877
DLX5 promotes osteosarcoma progression via activation of the NOTCH signaling pathway
点击查看 >>
Author：
Xiaojing Zhang, Huiqin Bian, Wei Wei, Qian Wang, Jinnan Chen, Ruoxuan Hei, Chen Chen, Xuan Wu, Haochun Yuan, Junxia Gu, Yaojuan Lu, Cheguo Cai, Qiping Zheng
IF：
6.1660
Publish_to：
American Journal of Cancer Research
PMID：
34249467
Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s
点击查看 >>
Author：
Li Yan-yang, Wang Xiao-jing, Su Yu-lin, Wang Qing, Huang Shao-wei, Pan Zeng-feng, Chen Yan-ping, Liang Jun-jie, Zhang Mei-ling, Xie Xue-qian, Wu Zhi-yun, Chen Jin-yan, Zhou Lian, Luo Xia
IF：
6.1500
Publish_to：
ACTA PHARMACOLOGICA SINICA
PMID：
34671110
Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway
点击查看 >>
Author：
Li Fudong, Sun Xiaofei, Sun Kaiqiang, Kong Fanqi, Jiang Xin, Kong Qingjie
IF：
6.1000
Publish_to：
Neural Regeneration Research
PMID：
38103247
Anti-Aging Effects of R-Phycocyanin from Porphyra haitanensis on HUVEC Cells and Drosophila melanogaster
点击查看 >>
Author：
Yanyu Feng, Hanjin Lu, Jiamiao Hu, Baodong Zheng, Yi Zhang
IF：
6.0850
Publish_to：
Marine Drugs
PMID：
35892936
GLIS Family Zinc Finger 1 was First Linked With Preaxial Polydactyly I in Humans by Stepwise Genetic Analysis
点击查看 >>
Author：
Jin Jie-Yuan, Wu Pan-Feng, Luo Fang-Mei, Guo Bing-Bing, Zeng Lei, Fan Liang-Liang, Tang Ju-Yu, Xiang Rong
IF：
6.0810
Publish_to：
Frontiers in Cell and Developmental Biology
PMID：
35087831
Krüppel-like factor 15 integrated autophagy and gluconeogenesis to maintain glucose homeostasis under 20-hydroxyecdysone regulation
点击查看 >>
Author：
Xiao-Pei Wang, Zhen Huang, Yan-Li Li, Ke-Yan Jin, Du-Juan Dong, Jin-Xing Wang, Xiao-Fan Zhao
IF：
6.0200
Publish_to：
PLoS Genetics
PMID：
35696369
SUZ12 participates in the proliferation of PNH clones by regulating histone H3K27me3 levels
点击查看 >>
Author：
Yingying Chen, Hui Liu, Lijie Zeng, Liyan Li, Dan Lu, Zhaoyun Liu, Rong Fu
IF：
6.0110
Publish_to：
JOURNAL OF LEUKOCYTE BIOLOGY
PMID：
34990019
Rutaecarpine Attenuates Oxidative Stress-Induced Traumatic Brain Injury and Reduces Secondary Injury via the PGK1/KEAP1/NRF2 Signaling Pathway
点击查看 >>
Author：
Min Xu, Liu Li, Hua Liu, Wei Lu, Xiaoyang Ling, Mingjie Gong
IF：
5.9880
Publish_to：
Frontiers in Pharmacology
PMID：
35529443
Daturataturin A, a withanolide in Datura metel L., induces HaCaT autophagy through the PI3K-Akt-mTOR signaling pathway
点击查看 >>
Author：
Zheng Wei, Tingting Li, Yanping Sun, Huilin Su, Yuanning Zeng, Qiuhong Wang, Haixue Kuang
IF：
5.8820
Publish_to：
PHYTOTHERAPY RESEARCH
PMID：
33560581
Lysyl Oxidase-like Protein Recognizes Viral Envelope Proteins and Bacterial Polysaccharides against Pathogen Infection via Induction of Expression of Antimicrobial Peptides
点击查看 >>
Author：
Peng-Yuan Lu, Guo-Juan Niu, Pan-Pan Hong, Jin-Xing Wang
IF：
5.8180
Publish_to：
Viruses-Basel
PMID：
36146878
Effects of Sodium Ferulate on Cardiac Hypertrophy Are via the CaSR-Mediated Signaling Pathway
点击查看 >>
Author：
Chen Panpan, Wen Zhaoqin, Shi Wanlan, Li Zhongli, Chen Xiaoyan, Gao Yang, Xu Shangfu, Gong Qihai, Deng Jiang
IF：
5.8110
Publish_to：
Frontiers in Pharmacology
PMID：
34690749
Torachrysone-8-O-β-d-glucoside mediates anti-inflammatory effects by blocking aldose reductase-catalyzed metabolism of lipid peroxidation products
点击查看 >>
Author：
Wen-long Zhao, Di Xu, Jun-song Wang
IF：
5.8000
Publish_to：
BIOCHEMICAL PHARMACOLOGY
PMID：
37981172
ZNF24 regulates the progression of KRAS mutant lung adenocarcinoma by promoting SLC7A5 translation
点击查看 >>
Author：
Daqi Jia, Leilei Li, Peng Wang, Qiang Feng, Xinyan Pan, Peng Lin, Shuling Song, Lilin Yang, Julun Yang
IF：
5.7380
Publish_to：
Frontiers in Oncology
PMID：
36505791
Anti-inflammation of torachrysone-8-O-β-ᴅ-glucoside by hurdling over morphological changes of macrophages
点击查看 >>
Author：
Wenlong Zhao, Di Xu, Lin Zhang, Huihui Meng, Qi Zheng, Junsong Wang
IF：
5.7140
Publish_to：
INTERNATIONAL IMMUNOPHARMACOLOGY
PMID：
35092943
Therapeutic Effect and Safety Evaluation of Naringin on Klebsiella pneumoniae in Mice
点击查看 >>
Author：
Guanyu Zhao, Qilin Huang, Xiaohan Jing, Lina Huang, Chen Liu, Xiangyi Pan, Zhaorong Li, Sifan Li, Zhengying Qiu, Ruihua Xin
IF：
5.6000
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
PMID：
37958922
TSG-6 Inhibits the NF-κB Signaling Pathway and Promotes the Odontogenic Differentiation of Dental Pulp Stem Cells via CD44 in an Inflammatory Environment
点击查看 >>
Author：
Ying Wang, Yulang Xie, Ningning Xue, Hao Xu, Dunfang Zhang, Ning Ji, Qianming Chen
IF：
5.5000
Publish_to：
Biomolecules
PMID：
38540786
Metabolomic Profiles in the Intestine of Shrimp Infected by White Spot Syndrome Virus and Antiviral Function of the Metabolite Linoleic Acid in Shrimp
点击查看 >>
Author：
Li, Cang, Yang, Ming-Chong, Hong, Pan-Pan, Zhao, Xiao-Fan, Wang, Jin-Xing
IF：
5.4220
Publish_to：
JOURNAL OF IMMUNOLOGY
PMID：
33863791
Icariin ameliorates glycolytic dysfunction in Alzheimer's disease models by activating the Wnt/β-catenin signaling pathway
点击查看 >>
Author：
Ju Liu, Ai-Hong Wei, Ting-Ting Liu, Xin-Hao Ji, Ying Zhang, Fei Yan, Mei-Xiang Chen, Jin-Bo Hu, Shao-Yu Zhou, Jing-Shan Shi, Hai Jin, Feng Jin
IF：
5.4000
Publish_to：
FEBS Journal
PMID：
38400523
Hepatoprotective effects of ginsenoside Rk3 in acetaminophen-induced liver injury in mice by activation of autophagy
点击查看 >>
Author：
Linlin Qu, Rongzhan Fu, Xiaoxuan Ma, Daidi Fan
IF：
5.3960
Publish_to：
Food & Function
PMID：
34397062
Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3–Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury
点击查看 >>
Author：
Chengting Luo, Wenxi Ding, Changmei Yang, Wenhao Zhang, Xiaohui Liu, Haiteng Deng
IF：
5.3700
Publish_to：
JOURNAL OF PROTEOME RESEARCH
PMID：
35699728
A bioinformatics and transcriptomics based investigation reveals an inhibitory role of Huanglian-Renshen-Decoction on hepatic glucose production of T2DM mice via PI3K/Akt/FoxO1 signaling pathway
点击查看 >>
Author：
Fan Wu, Qingqing Shao, Qingsong Xia, Meilin Hu, Yan Zhao, Dingkun Wang, Ke Fang, Lijun Xu, Xin Zou, Zhuo Chen, Guang Chen, Fuer Lu
IF：
5.3400
Publish_to：
PHYTOMEDICINE
PMID：
33636476
MTHFD2 promotes tumorigenesis and metastasis in lung adenocarcinoma by regulating AKT/GSK-3β/β-catenin signalling
点击查看 >>
Author：
Yangfeng Shi, Yiming Xu, Jianchang Yao, Chao Yan, Hua Su, Xue Zhang, Enguo Chen, Kejing Ying
IF：
5.3100
Publish_to：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
PMID：
34121323
4-octyl itaconate improves the viability of D66H cells by regulating the KEAP1-NRF2-GCLC/HO-1 pathway
点击查看 >>
Author：
Yanrui Chen, Zhenying Wang, Yali Song, Nan Chen, Jing Guo, Wenmin Liu, Keying Guo, Xia Ling, Li Zhang
IF：
5.3000
Publish_to：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
PMID：
36916028
DHA/EPA-Enriched Phosphatidylcholine Suppresses Tumor Growth and Metastasis via Activating Peroxisome Proliferator-Activated Receptor γ in Lewis Lung Cancer Mice
点击查看 >>
Author：
Yuanyuan Liu, Yingying Tian, Weizhen Cai, Yao Guo, Changhu Xue, Jingfeng Wang
IF：
5.2790
Publish_to：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
PMID：
33406839
New dammarane-type triterpenoid saponins from Gynostemma pentaphyllum and their Sirt1 agonist activity
点击查看 >>
Author：
Yun-Yun Lou, Xian Zheng, Ya-Ping Huang, Long Mu, Xiao-Gai Zhang, Zhi-Wei Zhao, Zhe Song, Jian Zhang, Zhi-Qi Yin, Ke Pan
IF：
5.2750
Publish_to：
BIOORGANIC CHEMISTRY
PMID：
34562675
A Mechanism of Isoorientin-Induced Apoptosis and Migration Inhibition in Gastric Cancer AGS Cells
点击查看 >>
Author：
Tong Zhang, Yun-Hong Xiu, Hui Xue, Yan-Nan Li, Jing-Long Cao, Wen-Shuang Hou, Jian Liu, Yu-He Cui, Ting Xu, Ying Wang, Cheng-Hao Jin
IF：
5.2150
Publish_to：
Pharmaceuticals
PMID：
36558992
Oleanolic Acid Inhibits SCD1 Gene Expression to Ameliorate Fructose-Induced Hepatosteatosis through SREBP1c-Dependent and -Independent Mechanisms
点击查看 >>
Author：
Ling Yao, Meng Wang, Jun Zhang, Xianqin Luo, Chunlin Yuan, Ruojun Bai, Tongzhuang Wang, Yumeng Xi, Chunli Li, Dazhi Ke, Johji Yamahara, Yuhao Li, Yongfen Yi, Shang Wang, Jianwei Wang
IF：
5.2000
Publish_to：
MOLECULAR NUTRITION & FOOD RESEARCH
PMID：
36972071
Andrographolide inhibits the growth of human osteosarcoma cells by suppressing Wnt/β-catenin, PI3K/AKT and NF-κB signaling pathways
点击查看 >>
Author：
Huakun Huang, Qiuping Lu, Xiaohui Yuan, Ping Zhang, Caihong Ye, Mengqi Wei, Chunmei Yang, Lulu Zhang, Yanran Huang, Xiaoji Luo, Jinyong Luo
IF：
5.1680
Publish_to：
CHEMICO-BIOLOGICAL INTERACTIONS
PMID：
35917943
Ovatodiolide induces autophagy-mediated cell death through the p62-Keap1-Nrf2 signaling pathway in chronic myeloid leukemia cells
点击查看 >>
Author：
Qingqing Xia, Jing Xie, Jianguo Zhang, Lingmin Zhang, Yingying Zhou, Bihong Zhu, Yanfang Wu, Zaixing Yang, Jie Li
IF：
5.1000
Publish_to：
CHEMICO-BIOLOGICAL INTERACTIONS
PMID：
38000454
XQ-1H promotes cerebral angiogenesis via activating PI3K/Akt/GSK3β/β-catenin/VEGF signal in mice exposed to cerebral ischemic injury
点击查看 >>
Author：
Yuxiang Fei, Bo Zhao, Jianping Zhu, Weirong Fang, Yunman Li
IF：
5.0370
Publish_to：
LIFE SCIENCES
PMID：
33607158
Peimine-induced apoptosis and inhibition of migration by regulating reactive oxygen species-mediated MAPK/STAT3/NF-κB and Wnt/β-catenin signaling pathways in gastric cancer MKN-45 cells
点击查看 >>
Author：
Tong Zhang, Guo-Yan Liu, Jing-Long Cao, Yan-Nan Li, Hui Xue, Hai-Tao Wu, Cheng-Hao Jin
IF：
5.0040
Publish_to：
DRUG DEVELOPMENT RESEARCH
PMID：
36048972
SIRT6-mediated Runx2 downregulation inhibits osteogenic differentiation of human aortic valve interstitial cells in calcific aortic valve disease
点击查看 >>
Author：
Jiaqi Xiong, Wenfeng Lin, Chunze Yuan, Jinhui Bian, Yifei Diao, Xinyang Xu, Buqing Ni, Hui Zhang, Yongfeng Shao
IF：
5.0000
Publish_to：
EUROPEAN JOURNAL OF PHARMACOLOGY
PMID：
38365109
hUCMSCs reduce theca interstitial cells apoptosis and restore ovarian function in premature ovarian insufficiency rats through regulating NR4A1-mediated mitochondrial mechanisms
点击查看 >>
Author：
Luo Qianqian, Tang Yu, Jiang Zhonglin, Bao Hongchu, Fu Qiang, Zhang Hongqin
IF：
4.9820
Publish_to：
Reproductive Biology and Endocrinology
PMID：
35986315
Veratric acid alleviates liver ischemia/reperfusion injury by activating the Nrf2 signaling pathway
点击查看 >>
Author：
Qiwen Yu, Sanyang Chen, Hongwei Tang, Xiaodan Zhang, Ruolin Tao, Zhiping Yan, Jihua Shi, Wenzhi Guo, Shuijun Zhang
IF：
4.9320
Publish_to：
INTERNATIONAL IMMUNOPHARMACOLOGY
PMID：
34749250
Atractylodin Induces Apoptosis and Inhibits the Migration of A549 Lung Cancer Cells by Regulating ROS-Mediated Signaling Pathways
点击查看 >>
Author：
Tong Zhang, Shu-Mei Li, Yan-Nan Li, Jing-Long Cao, Hui Xue, Chang Wang, Cheng-Hao Jin
IF：
4.9270
Publish_to：
MOLECULES
PMID：
35566297
Nrf2 mediates the effects of shionone on silica-induced pulmonary fibrosis
点击查看 >>
Author：
Wang Guiyun, Xie Weixi, Deng Lang, Huang Xiaoting, Sun Mei, Liu Wei, Tang Siyuan
IF：
4.9000
Publish_to：
Chinese Medicine
PMID：
38898509
Sichen Formula Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Blocking the TLR4 Signaling Pathways
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Author：
Li-Shan Yan, Shuang Cui, Brian Chi-Yan Cheng, Xing-Bin Yin, Yi-Wei Wang, Xin-Yu Qiu, Ci-Ren Nima, Yi Zhang, Shuo-Feng Zhang
IF：
4.8000
Publish_to：
Drug Design Development and Therapy
PMID：
36756190
An LPS-induced TNF-α factor involved in immune response of oyster Crassostrea gigas by regulating haemocytes apoptosis
点击查看 >>
Author：
Chunyu Tang, Xue Qiao, Yuhao Jin, Wenwen Yang, Zhuo Yu, Lingling Wang, Linsheng Song
IF：
4.7000
Publish_to：
FISH & SHELLFISH IMMUNOLOGY
PMID：
38521141
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study
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Author：
Shen Yue, Teng Li, Qu Yuhan, Huang Yuehui, Peng Yi, Tang Min, Fu Qiang
IF：
4.6570
Publish_to：
INFLAMMATION
PMID：
36348189
Integrinβ1/FAK/ERK signalling pathway is essential for Chinese mitten crab Eriocheir sinensis hemocyte survival
点击查看 >>
Author：
Yuehong Zhao, Xiaoli Zhang, Xiaona Zhang, Guoqing Shen, Weiwei Li, Qun Wang
IF：
4.6220
Publish_to：
FISH & SHELLFISH IMMUNOLOGY
PMID：
36470403
Eplerenone reduces lymphangiogenesis in the contralateral kidneys of UUO rats
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Author：
Hao Juan, Qiang Panpan, Fan Lili, Xiong Yunzhao, Chang Yi, Yang Fan, Wang Xiangting, Shimosawa Tatsuo, Mu Shengyu, Xu Qingyou
IF：
4.6000
Publish_to：
Scientific Reports
PMID：
38693148
A detoxification pathway initiated by a nuclear receptor TcHR96h in Tetranychus cinnabarinus (Boisduval)
点击查看 >>
Author：
Xiang Wen, Kaiyang Feng, Juan Qin, Peng Wei, Peng Cao, Youjun Zhang, Zhiguang Yuchi, Lin He
IF：
4.5000
Publish_to：
PLoS Genetics
PMID：
37708138
Generation of 3′-OH terminal–triggered encoding of multicolor fluorescence for simultaneous detection of different DNA glycosylases
点击查看 >>
Author：
Zhang Huige, Gao Zixi, He Fei, Lan Jingfeng, Chai Hailong, Zhang Shiqian, Zuo Xianwei, Chen Hongli, Chen Xingguo
IF：
4.4780
Publish_to：
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
PMID：
35982252
Downregulation of activating transcription factor 4 attenuates lysophosphatidycholine-induced inflammation via the NF-κB pathway
点击查看 >>
Author：
Yingchao Gong, Qingfeng Li, Zetao Ma, Tingting Jin, Jun Lin, Qingbo Lv, Meihui Wang, Guosheng Fu, Shengjie Xu
IF：
4.4320
Publish_to：
EUROPEAN JOURNAL OF PHARMACOLOGY
PMID：
34582847
TGF-β3 Protects Neurons Against Intermittent Hypoxia-Induced Oxidative Stress and Apoptosis Through Activation of the Nrf-2/KEAP1/HO-1 Pathway via Binding to TGF-βRI
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Author：
Huang Yinpei, Liu Zhili, Wang Xin, Li Yaoxu, Liu Lian, Li Bing
IF：
4.4000
Publish_to：
NEUROCHEMICAL RESEARCH
PMID：
37140776
LINC00665 Targets miR-214-3p/MAPK1 Axis to Accelerate Hepatocellular Carcinoma Growth and Warburg Effect
点击查看 >>
Author：
Hongyu Wan, Yi Tian, Juan Zhao, Xiao Su
IF：
4.3750
Publish_to：
Journal of Oncology
PMID：
34804162
Leukemia inhibitory factor prevents chicken follicular atresia through PI3K/AKT and Stat3 signaling pathways
点击查看 >>
Author：
Juan Dong, Changquan Guo, Shuo Zhou, An Zhao, Jian Li, Yuling Mi, Caiqiao Zhang
IF：
4.3690
Publish_to：
MOLECULAR AND CELLULAR ENDOCRINOLOGY
PMID：
34990741
Silencing of adipocyte enhancer-binding protein 1 (AEBP1) alleviates renal fibrosis in vivo and in vitro via inhibition of the β-catenin signaling pathway
点击查看 >>
Author：
Liu Naiquan, Liu Dajun, Cao Shiyu, Lei Jing
IF：
4.3000
Publish_to：
Human Cell
PMID：
36738398
Regulation of viral gene expression by duck enteritis virus UL54
点击查看 >>
Author：
Chaoyue Liu, Anchun Cheng, Mingshu Wang, Shun Chen
IF：
4.2590
Publish_to：
Scientific Reports 7, Article number: 1076 (2017)
PMID：
28432334
Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus
点击查看 >>
Author：
An Dong, Qi Xiuting, Li Kunpeng, Xu Weixing, Wang Yue, Chen Xi, Sha Sha, Wu Chunfeng, Du Yimei, Chen Lei
IF：
4.2310
Publish_to：
CELLULAR AND MOLECULAR NEUROBIOLOGY
PMID：
35840809
NDRG3 regulates imatinib resistance by promoting β‑catenin accumulation in the nucleus in chronic myelogenous leukemia
点击查看 >>
Author：
Xiao Wang, Simin Rong, Yunxiao Sun, Baohui Yin, Xiancong Yang, Xiaoqing Lu, Hongfang Sun, Yunfei Yan, Guangbin Sun, Yan Liang, Pingyu Wang, Shuyang Xie, Youjie Li
IF：
4.2000
Publish_to：
ONCOLOGY REPORTS
PMID：
37350410
Anti-inflammation of hydrogenated isoflavones in LPS-stimulated RAW264.7 cells via inhibition of NF-κB and MAPK signaling pathways
点击查看 >>
Author：
Keting Li, Wenshu Hu, Yaobin Yang, Hongmei Wen, Wei Li, Bo Wang
IF：
4.1740
Publish_to：
MOLECULAR IMMUNOLOGY
PMID：
36495817
Biogenic selenium nanoparticles synthesized by Lactobacillus casei ATCC 393 alleviate diquat-induced intestinal barrier dysfunction in C57BL/6 mice through their antioxidant activity
点击查看 >>
Author：
乔磊
IF：
4.1710
Publish_to：
PMID：
32243488
18β-Glycyrrhetinic Acid Has Anti-Cancer Effects via Inducing Apoptosis and G2/M Cell Cycle Arrest, and Inhibiting Migration of A549 Lung Cancer Cells
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Author：
Ying-Hua Luo, Cheng Wang, Wan-Ting Xu, Yu Zhang, Tong Zhang, Hui Xue, Yan-Nan Li, Zhong-Ren Fu, Ying Wang, Cheng-Hao Jin
IF：
4.1470
Publish_to：
OncoTargets and Therapy
PMID：
34712051
PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis
点击查看 >>
Author：
Xiaoxue Meng, Lu Zhang, Bing Han, Zheng Zhang
IF：
4.1190
Publish_to：
ENVIRONMENTAL TOXICOLOGY
PMID：
34351043
Circ_SNX27 regulates hepatocellular carcinoma development via miR-637/FGFR1 axis
点击查看 >>
Author：
Hua Li, Bingli Liu, Xin Xu, Shunle Li, Di Zhang, Qingfeng Liu
IF：
4.1090
Publish_to：
ENVIRONMENTAL TOXICOLOGY
PMID：
36029209
Alantolactone suppresses the metastatic phenotype and induces the apoptosis of glioblastoma cells by targeting LIMK kinase activity and activating the cofilin/G‑actin signaling cascade
点击查看 >>
Author：
Xun Wang, Shuang Zou, Tong Ren, Li-Jun Zhao, Li-Fei Yu, Xiang-Yu Li, Xin Yan, Li-Jun Zhang
IF：
4.1010
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
PMID：
33649781
CgIκB2 negatively regulates the expression of interferon-like protein by Rel/NF-κB signal in Crassostrea gigas
点击查看 >>
Author：
Jixiang Niu, Sicong Wang, Xue Qiao, Simiao Yu, Zhuo Yu, Yuhao Jin, Mengyue Huang, Lingling Wang, Linsheng Song
IF：
4.1000
Publish_to：
FISH & SHELLFISH IMMUNOLOGY
PMID：
39173983
Cerium Oxide Nanoparticles Promote Osteoplastic Precursor Differentiation by Activating the Wnt Pathway
点击查看 >>
Author：
Luo Junchao, Zhu Senbo, Tong Yu, Zhang Yin, Li Yong, Cao Li, Kong Mingxiang, Luo Min, Bi Qing, Zhang Qiong
IF：
4.0810
Publish_to：
BIOLOGICAL TRACE ELEMENT RESEARCH
PMID：
35230639
Quercetin Inhibits Pyroptosis in Diabetic Cardiomyopathy through the Nrf2 Pathway
点击查看 >>
Author：
Zhang Wei, Zhou Jing, Kang Pinfang, Shi Chao, Qian Shaohuan
IF：
4.0610
Publish_to：
Journal of Diabetes Research
PMID：
36624860
Synergistic regulation of methylation and SP1 on MAGE-D4 transcription in glioma
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Author：
Chang Liu, Yingying Ge, Bin Luo, Xiaoxun Xie, Ning Shen, Weixia Nong, Shuiqing Bi, Lina Lin, Xing Wei, Song Wu, Shaowen Xiao, Qingmei Zhang
IF：
4.0600
Publish_to：
American Journal of Translational Research
PMID：
34017386
Tea polyphenols ameliorates memory decline in aging model rats by inhibiting brain TLR4/NF-κB inflammatory signaling pathway caused by intestinal flora dysbiosis
点击查看 >>
Author：
Chenmeng Song, Yusen Zhang, Le Cheng, Mengqian Shi, Xuemin Li, Luping Zhang, Haifeng Zhao
IF：
4.0320
Publish_to：
EXPERIMENTAL GERONTOLOGY
PMID：
34265410
Trans-anethole exerts protective effects on lipopolysaccharide-induced acute jejunal inflammation of broilers via repressing NF-κB signaling pathway
点击查看 >>
Author：
Yichun Tong, Caiyun Yu, Shun Chen, Xianglei Zhang, Zaibin Yang, Tian Wang
IF：
4.0140
Publish_to：
POULTRY SCIENCE
PMID：
36565631
Pan-cancer analysis revealed prognosis value and immunological relevance of RAMPs
点击查看 >>
Author：
Sha Yang, Renzheng Huan, Mei Deng, Tao Luo, Shuo Peng, Yunbiao Xiong, Guoqiang Han, Jian Liu, Jiqin Zhang, Ying Tan
IF：
4.0000
Publish_to：
Heliyon
PMID：
38317990
The liver X receptor agonist T0901317 reduces the inflammation of alveolar epithelial cells induced by polyhexamethylene guanidine through inhibition of the NFκB signaling pathway
点击查看 >>
Author：
Lutang Wei, Yongzhong Guo, Xiaoqian Ding, Caihong Guo, Nan Ge, Dunqiang Ren, Hongmei Wang
IF：
3.9320
Publish_to：
Annals of Translational Medicine
PMID：
35071489
Antifatigue effect of sea buckthorn seed oil on swimming fatigue in mice
点击查看 >>
Author：
Zhonghua An, Yifan Wang, Xiangbo Li, Hong Jin, Yanling Gong
IF：
3.9000
Publish_to：
JOURNAL OF FOOD SCIENCE
PMID：
36916120
Resveratrol induces proliferation in preosteoblast cell MC3T3-E1 via GATA-1 activating autophagy
点击查看 >>
Author：
Liu Xiang, Tao Jun, Yao Yueyi, Yang Ping, Wang Juhui, Yu Mali, Hou Jianhong, Zhang Ying, Gui Li
IF：
3.8480
Publish_to：
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
PMID：
34637502
Chlorogenic acid, rutin, and quercetin from Lysimachia christinae alleviate triptolide-induced multi-organ injury in vivo by modulating immunity and AKT/mTOR signal pathway to inhibit ferroptosis and apoptosis
点击查看 >>
Author：
Xiaohui Wu, Junming Wang, Bingyin Li, Mingzhu Gong, Can Cao, Lingling Song, Lingyu Qin, Yanmei Wang, Yueyue Zhang, Yamin Li
IF：
3.8000
Publish_to：
TOXICOLOGY AND APPLIED PHARMACOLOGY
PMID：
36963520
Novel variant in BRAT1 with the lethal neonatal rigidity and multifocal seizure syndrome
点击查看 >>
Author：
Li Weixi, Wu Shuiyan, Xu Huizhong, Zhao Xiaoying, Pan Yizhi, Huang Hongbiao, Lv Haitao, Zhu Xueping, Liu Ying
IF：
3.7560
Publish_to：
PEDIATRIC RESEARCH
PMID：
33790413
Pygo2 activates BRPF1 via Pygo2–H3K4me2/3 interaction to maintain malignant progression in colon cancer
点击查看 >>
Author：
Jie Ling, Zhijie Tang, Wei Yang, Ye Li, Xiaoqiang Dong
IF：
3.7000
Publish_to：
EXPERIMENTAL CELL RESEARCH
PMID：
37423512
Scutellarin attenuates doxorubicin-induced oxidative stress, DNA damage, mitochondrial dysfunction, apoptosis and autophagy in H9c2 cells, cardiac fibroblasts and HUVECs
点击查看 >>
Author：
Li Zhou, Yonglong Han, Quanjun Yang, Bo Xin, Mengyi Chi, Yan Huo, Cheng Guo, Xipeng Sun
IF：
3.6850
Publish_to：
TOXICOLOGY IN VITRO
PMID：
35470029
PDGFRβ modulates aerobic glycolysis in osteosarcoma HOS cells via the PI3K/AKT/mTOR/c-Myc pathway
点击查看 >>
Author：
Hu-ying Tang, Jia-qi Guo, Bo-tao Sang, Jun-ning Cheng, Xiang-mei Wu
IF：
3.6260
Publish_to：
Biochemistry and Cell Biology
PMID：
34678088
MiR-214-3p plays a protective role in diabetic neuropathic rats by regulating Nav1.3 and TLR4
点击查看 >>
Author：
Bo Pang, Ling Qiao, Shaoxin Wang, Xin Guo, Yun Xie, Liping Han
IF：
3.6120
Publish_to：
CELL BIOLOGY INTERNATIONAL
PMID：
34296787
Celastrol ameliorates hypoxic-ischemic brain injury in neonatal rats by reducing oxidative stress and inflammation
点击查看 >>
Author：
Hu Yingying, Nan Yan, Lin Hongzhou, Zhao Qianlei, Chen Tingting, Tao Xiaoyue, Ding Bingqing, Lu Liying, Chen Shangqin, Zhu Jianghu, Guo Xiaoling, Lin Zhenlang
IF：
3.6000
Publish_to：
PEDIATRIC RESEARCH
PMID：
38763946
Melatonin attenuates restenosis after vascular injury in diabetic rats through activation of the Nrf2 signaling pathway
点击查看 >>
Author：
Xuebin Wang, Tianjia Li, Baitao Ma, Zhewei Zhao, Leng Ni, Rui Zhang, Shuai Niu, Changwei Liu
IF：
3.5750
Publish_to：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
PMID：
33640605
Disrupting methyl-CpG-binding protein 2 expression induces the transformation of induced pluripotent stem cell cardiomyocytes into pacemaker-like cells by insulin gene enhancer binding protein 1
点击查看 >>
Author：
Wei Zhang, Jianjun Gu, Yanxi Shi, Bichun Li, Xiang Gu
IF：
3.5000
Publish_to：
JOURNAL OF GENE MEDICINE
PMID：
36908084
Nicotinate-curcumin inhibits AngII-induced vascular smooth muscle cell phenotype switching by upregulating Daxx expression
点击查看 >>
Author：
Si-yu Sun, Yu-mei Cao, Yan-jie Huo, Fei Qiu, Wen-juan Quan, Chao-ping He, Yu Chen, Duan-fang Liao, Qin-hui Tuo
IF：
3.4050
Publish_to：
Cell Adhesion & Migration
PMID：
33843453
Caffeic Acid and Diabetic Neuropathy: Investigating Protective Effects and Insulin-like growth factor 1 (IGF-1)-related Antioxidative and Anti-inflammatory Mechanisms in Mice
点击查看 >>
Author：
Leina Hou, Jiaqi Ma, Xugang Feng, Jing Chen, Bu-huai Dong, Li Xiao, Xi Zhang, Bin Guo
IF：
3.4000
Publish_to：
Heliyon
PMID：
38975173
MiR-20a-5p overexpression prevented diabetic cardiomyopathy via inhibition of cardiomyocyte apoptosis, hypertrophy, fibrosis and JNK/NF-κB signalling pathway
点击查看 >>
Author：
Liu Xiaoyu, Guo Bingyan, Zhang Wei, Ma Bocong, Li Yongjun
IF：
3.3870
Publish_to：
JOURNAL OF BIOCHEMISTRY
PMID：
33837411
Ketogenic diet prevents paclitaxel-induced neuropathic nociception through activation of PPARγ signalling pathway and inhibition of neuroinflammation in rat dorsal root ganglion
点击查看 >>
Author：
Shanshan Zhong, Zhike Zhou, Xinyu Lin, Fangxi Liu, Chang Liu, Zhouyang Liu, Wenyun Deng, Xiuchun Zhang, Hongtao Chang, Chuansheng Zhao
IF：
3.3860
Publish_to：
EUROPEAN JOURNAL OF NEUROSCIENCE
PMID：
34318540
Curcumin Attenuates Ferroptosis-Induced Myocardial Injury in Diabetic Cardiomyopathy through the Nrf2 Pathway
点击查看 >>
Author：
Zhang Wei, Qian Shaohuan, Kang Pinfang, Shi Chao
IF：
3.3680
Publish_to：
Cardiovascular Therapeutics
PMID：
35909950
DhHP-6 alleviates inflammation and reduces vascular permeability by eliminating reactive oxygen species
点击查看 >>
Author：
Fanwei Meng, Junfeng Ke, Feng Guo, Jiaqing Yan, Liping Wang
IF：
3.3000
Publish_to：
FREE RADICAL RESEARCH
PMID：
37533406
The role of junctional adhesion molecule-C in trophoblast differentiation and function during normal pregnancy and preeclampsia
点击查看 >>
Author：
Chenrui Cao, Yimin Dai, Zhiyin Wang, Guangfeng Zhao, Honglei Duan, Xiangyu Zhu, Jingmei Wang, Mingming Zheng, Qiao Weng, Limin Wang, Wenjing Gou, Haili Zhang, Chanjuan Li, Dan Liu, Yali Hu
IF：
3.2870
Publish_to：
PLACENTA
PMID：
35032792
circNup188/miR-760–3p/Map3k8 axis regulates inflammation in cerebral ischemia
点击查看 >>
Author：
Hui Zhang, Jian Deng, Kangling Huang, Yibo He, Zhili Cai, Yitao He
IF：
3.2850
Publish_to：
MOLECULAR AND CELLULAR PROBES
PMID：
35636640
Sirtuin 3 Ameliorates Lung Senescence and Improves Type II Alveolar Epithelial Cell Function by Enhancing the FoxO3a-Dependent Antioxidant Defense Mechanism
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Author：
Jian-Xin Chen, Lei Yang, Lu Sun, Wei Chen, Jie Wu, Chun-Feng Zhang, Kai-Yu Liu, Long Bai, Hong-Guang Lu, Tong Gao, Hai Tian, Shu-Lin Jiang
IF：
3.2720
Publish_to：
STEM CELLS AND DEVELOPMENT
PMID：
34148409
α-Actinin1 promotes tumorigenesis and epithelial-mesenchymal transition of gastric cancer via the AKT/GSK3β/β-Catenin pathway
点击查看 >>
Author：
Siwen Zhang, Junfu Wang, Ting Chen, Jiancheng Wang, Ye Wang, Zhu Yu, Kun Zhao, Kaitian Zheng, Yeyang Chen, Zhen Wang, Bopei Li, Congjun Wang, Weijia Huang, Zhao Fu, Junqiang Chen
IF：
3.2690
Publish_to：
Bioengineered
PMID：
34546849
miR-4323 targets hepatoma-derived growth factor (HDGF) to suppress colorectal cancer cell proliferation
点击查看 >>
Author：
Cuifeng Xia, Qiang Li, Xianshuo Cheng, Tao Wu, Pin Gao
IF：
3.2500
Publish_to：
PATHOLOGY RESEARCH AND PRACTICE
PMID：
34314948
Lutein inhibits glutamate-induced apoptosis in HT22 cells via the Nrf2/HO-1 signaling pathway
点击查看 >>
Author：
Li Zhenhua, Cao Zhuohua, Chen Fangmei, Li Bin, Jin Hanyong
IF：
3.2000
Publish_to：
Frontiers in Neuroscience
PMID：
39193525
Micro/nano topological modification of TiO2 nanotubes activates Thy-1 signaling to control osteogenic differentiation of stem cells
点击查看 >>
Author：
Li Jinsheng, Deng Qing, Chen Junhao, Si Qiqi, Chen Jieru, Yang Liwen, Guo Zhiyun, Guo Tailin, Weng Jie
IF：
3.1000
Publish_to：
SLAS Discovery
PMID：
38169172
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway
点击查看 >>
Author：
Fei Sun, Jian Lin Zhou, Si Xing Wei, Ze Wen Jiang, Hao Peng
IF：
3.0610
Publish_to：
PeerJ
PMID：
35529482
Sp1 Controls the Basal Level of Interleukin-34 Transcription
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Author：
Minggui Lin, Xingyun Liu, Xinhui Zhang, Huimin Wang, Yu Fang, Xiaoting Wu, Anqi Yin, Wanqing Yang, Dong Zhang, Miaomiao Li, Ling Zhang, Songcheng Ying
IF：
3.0440
Publish_to：
IMMUNOLOGICAL INVESTIGATIONS
PMID：
36562687
YAP plays a protective role in T-2 toxin-induced inhibition of chondrocyte proliferation and matrix degradation
点击查看 >>
Author：
Hao-Nan Li, Bai-Ming Jin, Hua Zhang, Le-Le Liu, Meng-Yuan Li, Xiu-Juan Zheng, Xu-Ying Li, Ke-wei Wang
IF：
3.0350
Publish_to：
TOXICON
PMID：
35697129
Enhanced anticancer synergy of LOM612 in combination with selinexor: FOXO1 nuclear translocation-mediated inhibition of Wnt/β-catenin signaling pathway in breast cancer
点击查看 >>
Author：
Xu Shengxi, Shi Yingfang, Li Sen
IF：
3.0000
Publish_to：
CANCER CHEMOTHERAPY AND PHARMACOLOGY
PMID：
38051377
RHBDD1 promotes proliferation, migration, invasion and EMT in renal cell carcinoma via the EGFR/AKT signaling pathway
点击查看 >>
Author：
Mingyang Li, Licheng Cai, Xingyuan Wang, Yipeng Yu, Wengang Jian, Guochang Bao, Zhiming Gao, Junsheng Guo, Jian Zhang, Chunsheng Li, Cheng Zhang
IF：
2.9520
Publish_to：
Molecular Medicine Reports
PMID：
34581421
Acidic oligosaccharide sugar chain combined with hyperbaric oxygen delays D-galactose-induced brain senescence in mice via attenuating oxidative stress and neuroinflammation
点击查看 >>
Author：
Guimei Wang, Xiaolin Wang, Xiaoyue Zheng, Shuqin Sun, Jing Zhao, Ying Long, Yongjun Mao
IF：
2.9040
Publish_to：
NEUROSCIENCE RESEARCH
PMID：
35970311
Gamma-glutamyltransferase of Helicobacter pylori alters the proliferation, migration, and pluripotency of mesenchymal stem cells by affecting metabolism and methylation status
点击查看 >>
Author：
Wang Zeyu, Wang Weijun, Shi Huiying, Meng Lingjun, Jiang Xin, Pang Suya, Fan Mengke, Lin Rong
IF：
2.9020
Publish_to：
JOURNAL OF MICROBIOLOGY
PMID：
35437622
GALNT12 promotes fibrosarcoma growth by accelerating YAP1 nuclear localization
点击查看 >>
Author：
Site Yu, Wenjie Feng, Jizhang Zeng, Situo Zhou, Yinghua Peng, Pihong Zhang
IF：
2.9000
Publish_to：
Oncology Letters
PMID：
38020290
Integrating Network Pharmacology and Experimental Validation to Explore the Key Mechanism of Gubitong Recipe in the Treatment of Osteoarthritis
点击查看 >>
Author：
Guang-yao Chen, Xiao-yu Liu, Jing Luo, Xin-bo Yu, Yi Liu, Qing-wen Tao
IF：
2.8090
Publish_to：
Computational and Mathematical Methods in Medicine
PMID：
35720033
The TLR4/NF-κB signaling pathway-mediated type 2 skewing of T helper cell in cough variant asthma was counteracted by ethanol extract of Anacyclus pyrethrum root
点击查看 >>
Author：
Jun Zheng, Rui Zhang, Changjiang Liu, Hao Yang, Xiaoyue Jin
IF：
2.8000
Publish_to：
IMMUNOBIOLOGY
PMID：
36990039
Scutellarin Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Myocardial Fibrosis, Apoptosis and Autophagy in Rats
点击查看 >>
Author：
Xipeng Sun, Li Zhou, Yonglong Han, Quanjun Yang, Xingxia Li, Bo Xin, Mengyi Chi, Yaxian Wang, Cheng Guo
IF：
2.7450
Publish_to：
CHEMISTRY & BIODIVERSITY
PMID：
36419360
MEK1/2 inhibitors induce class I alcohol dehydrogenase (ADH1) expression by regulating farnesoid X receptor in hepatic cell lines and C57BL/6J mouse
点击查看 >>
Author：
Wang Xiaolin, Yang Yanfang, Chen Yuanli, Duan Yajun, Han Jihong, Yang Xiaoxiao
IF：
2.7420
Publish_to：
MOLECULAR BIOLOGY REPORTS
PMID：
35338439
Chemical characterization of Tianshan green tea polysaccharides and its protective effects on cell oxidative injury
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Author：
Jianbing Liu, Jun Lin, Zuohua Huang, Qiuxia Zheng, Feng Lin, Liyun Wu
IF：
2.7200
Publish_to：
JOURNAL OF FOOD BIOCHEMISTRY
PMID：
34825388
Baicalin facilitates remyelination and suppresses neuroinflammation in rats with chronic cerebral hypoperfusion by activating Wnt/β-catenin and inhibiting NF-κB signaling
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Author：
Yining Xiao, Tianyuan Guan, Xiaofeng Yang, Jing Xu, Jiawei Zhang, Qianqian Qi, Zhenjie Teng, Yanhong Dong, Yaran Gao, Meixi Li, Nan Meng, Peiyuan Lv
IF：
2.7000
Publish_to：
BEHAVIOURAL BRAIN RESEARCH
PMID：
36707260
Astragaloside IV attenuates IL-1β-induced intervertebral disc degeneration through inhibition of the NF-κB pathway
点击查看 >>
Author：
Tian Yueyang, Chu Xu, Huang Qia, Guo Xing, Xue Yuan, Deng Weimin
IF：
2.6770
Publish_to：
Journal of Orthopaedic Surgery and Research
PMID：
36527065
Vascular Protective Effects of Malus toringoides (Rehd.) Hughes Extracts and their Mechanism in Diabetic Rats and HUVECs
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Author：
Xiangyu Wang, Tong Wang, Liying Gao, Tsering Dikye, Linsha Dong, Ruiying Yuan, Ning Meng, Jing Yang, Eun-Rhan Woo, Dong-Sung Lee, Yuefei Wang, Bin Li, Shan Huang
IF：
2.6500
Publish_to：
Evidence-based Complementary and Alternative Medicine
PMID：
36310615
Asperuloside ameliorates lipopolysaccharide-induced primary human periodontal ligament cell injury by decreasing TLR4 expression and NF-κB activation
点击查看 >>
Author：
Xiaodan Fan, Chun Zhou, Cheng Huang, Junye Zhang
IF：
2.6350
Publish_to：
ARCHIVES OF ORAL BIOLOGY
PMID：
34174589
Total Flavonoids of Rhizoma Drynariae Restore the MMP/TIMP Balance in Models of Osteoarthritis by Inhibiting the Activation of the NF- and PI3K/AKT Pathways
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Author：
Guang-Yao Chen, Jia-Qi Chen, Xiao-Yu Liu, Yuan Xu, Jing Luo, Yi-Fei Wang, Tong-Liang Zhou, Ze-Ran Yan, Li Zhou, Qing-Wen Tao
IF：
2.6300
Publish_to：
Evidence-based Complementary and Alternative Medicine
PMID：
33995548
Chidamide enhances T-cell-mediated anti-tumor immune function by inhibiting NOTCH1/NFATC1 signaling pathway in ABC-type diffuse large B-cell lymphoma
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Author：
Li Li, Wenjing Yang, Yuanyuan Pan, Ruyu Ye, Yu Wang, Sijia Li, Haoyan Jiang, Qi Zhang, Xiaobo Wang, Jinsong Yan
IF：
2.6000
Publish_to：
LEUKEMIA & LYMPHOMA
PMID：
38497543
Blood exosome PD-L1 is associated with PD-L1 expression measured by immunohistochemistry, and lymph node metastasis in lung cancer
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Author：
Zhen Zhang, Weizhong Jin, Kai Xu, Xiaofang Zheng, You Zhou, Man Luo, Chenhong Yan, Xiuxiu Zheng, Er Jin
IF：
2.5860
Publish_to：
TISSUE & CELL
PMID：
36228365
Effects of undescribed iridoids in Patrinia punctiflora on insulin resistance in HepG2 cells
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Author：
Li Wang, Yi-Xiao Chen, Xin-Jing Meng, Hai-Yang Liang, Ya-Dan Zhang, Hui-Hui Zhou, Yu-Hang Liu, Xiao-Yu Chen, Zhen-Hua Liu, Shi-Ming Li, Wen-Yi Kang
IF：
2.5000
Publish_to：
FITOTERAPIA
PMID：
39098734
Baicalein pre‑treatment alleviates hepatic ischemia/reperfusion injury in mice by regulating the Nrf2/ARE pathway
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Author：
Yi Zhou, Zhi Tan, Hao Huang, Yonglian Zeng, Shilian Chen, Jie Wei, Guozhen Huang, Chaosi Qian, Guandou Yuan, Songqing He
IF：
2.4470
Publish_to：
Experimental and Therapeutic Medicine
PMID：
34650628
Eriocalyxin B alleviated ischemic cerebral injury via limiting microglia-mediated excessive neuroinflammation in mice
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Author：
Yanqiang CHEN, Cong ZHANG, Liming ZHAO, Rong CHEN, Peipei ZHANG, Junxia LI, Xueping ZHANG, Xiangjian ZHANG
IF：
2.4000
Publish_to：
EXPERIMENTAL ANIMALS
PMID：
37839867
Characterization of the Eimeria tenella rhoptry protein with a nuclear localization sequence (EtROP30)
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Author：
Bingxiang Wang, Ningning Zhao, Yakun Wang, Lingyu Sun, Hongmei Li, Zhang Xiao, Zhao Xiaomin
IF：
2.3830
Publish_to：
PARASITOLOGY RESEARCH
PMID：
35314894
Cyclopeptide Inhibitors Target the N-Terminal Tail of STING and Alleviate Autoinflammation
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Author：
Junmin Quan, Xiaoquan Wang, Anqi Cao, Wenlv Zheng
IF：
2.3000
Publish_to：
CHEMISTRY & BIODIVERSITY
PMID：
38997793
Ajania purpurea Extract Attenuates LPS-Induced Inflammation in RAW264.7 Cells and Peritonitis Mice
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Author：
Xiangyu Wang, Zhuoma Dongzhi, Yan Li, Mi Xie, Xinyu Li, Ruiying Yuan, Bin Li, Pharkphoom Panichayupakaranant, Shan Huang
IF：
2.2640
Publish_to：
BIOLOGICAL & PHARMACEUTICAL BULLETIN
PMID：
36450537
LncRNA UCA1 alleviates aberrant hippocampal neurogenesis through regulating miR-375/SFRP1-mediated WNT/β-catenin pathway in kainic acid-induced epilepsy:
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Author：
Limei Diao, Haichun Yu, Huaqiong Li, Yueqiang Hu, Mingfen Li, Qianchao He, Ling Lu, Huan Li, Xianqiu Liao
IF：
2.1490
Publish_to：
ACTA BIOCHIMICA POLONICA
PMID：
33829718
GLIS Family Zinc Finger 3 Promotes Triple-Negative Breast Cancer Progression by Inducing Cell Proliferation, Migration and Invasion, and Activating the NF-κB Signaling Pathway
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Author：
Chenhao Li, Cuizhi Geng
IF：
2.0000
Publish_to：
BIOLOGICAL & PHARMACEUTICAL BULLETIN
PMID：
36724950
Mechanism of Shengmai Injection on Anti-Sepsis and Protective Activities of Intestinal Mucosal Barrier in Mice
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Author：
Lu Juan, Yu Yue, Wang Xiao-jing, Chai Rui-ping, Lyu Xin-kai, Deng Ming-hui, Hu Mei-geng, Qi Yun, Chen Xi
IF：
1.9780
Publish_to：
Chinese Journal of Integrative Medicine
PMID：
34241804
EID1 plays a protective role in early-onset pre-eclampsia via promoting proliferation and invasion in trophoblast cells
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Author：
Ying Li Jiuxiang Feng Yue Bian Wei Cheng Chong Qiao
IF：
1.4900
Publish_to：
FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
PMID：
35038162
Effect of miR-27b-3p and Nrf2 in human retinal pigment epithelial cell induced by high-glucose
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Author：
Qiao-Ling Lai, Ting Xie, Wei-Dong Zheng, Yan Huang
IF：
1.4000
Publish_to：
International Journal of Ophthalmology
PMID：
37854382
技术问答
（6）
注意：
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请问抽出来的核蛋白可以直接用于EMSA实验吗?2023-11-27 09:18:43
您好，R0050试剂盒中的抽提试剂是不含SDS等变性剂成分的，但含有对蛋白质变性作用较弱的非离子型和离子型去垢剂成分，可能会对蛋白的活性有影响。
你好，提核蛋白时，贴壁细胞如何收集?2023-11-07 14:06:48
您好，可以用细胞刮刀收集细胞，或用EDTA消化后吹打下细胞（最好不用胰酶硝化，以免胰酶消化目的蛋白）。
如果组织的重量增加，那所需加入的细胞浆与细胞核蛋白抽提试剂的体积是否需要按比例增加？2023-10-07 09:09:45
请问R0050核蛋白提取试剂盒，操作方法第8项得到的细胞浆蛋白里面包括细胞器中的蛋白，细胞器膜蛋白和细胞膜蛋白吗?2023-09-28 09:58:52
您好，胞浆蛋白主要是胞质内可溶性蛋白，如需获取膜蛋白、细胞器膜蛋白等需要用膜蛋白提取试剂盒等来做。
该试剂盒提取的浆蛋白和核蛋白可以用于下游的那些实验?2023-05-21 10:07:54
您好，可用于Western blot等实验。